Clinical Studies

Interstitial Cystitis Studies

Women and Men Needed to Participate in a Clinical Research Study of an Oral Investigational Drug for Interstitial Cystitis/Bladder Pain Syndrome  
 
The LEADERSHIP 301 Trial: A 12-Week, Randomized, Multi-center, Double-Blind, Placebo-Controlled, 3-Arm, Parallel-Group, Phase 3 Trial to Evaluate the Efficacy and Safety of 2 Doses of AQX-1125 Targeting the SHIP1 Pathway in Subjects with Interstitial Cystitis/Bladder Pain Syndrome Followed by 14 or 40-Week Extension Periods
 
Sponsor: Aquinox Pharmaceuticals (Canada) Inc.
 
Purpose: The purpose of the LEADERSHIP 301 Trial is to learn if an investigational drug, AQX-1125, may reduce the bladder pain of interstitial cystitis/bladder pain syndrome (IC/BPS) and relieve other symptoms such as urinary urgency and frequency. The study drug is a new type of medication that may help reduce inflammation in the bladder. An earlier clinical study in women with IC/BPS showed that the women who took the study drug every day for 6 weeks experienced reduced bladder pain and improved symptoms compared to those who took placebo.
 
EligibilityYou may qualify if you: i) Are between the ages of 18 and 80. ii) Have been diagnosed with interstitial cystitis/bladder pain syndrome (IC/BPS) for at least 3 months. iii) Have consistently experienced moderate to severe bladder pain, urinary urgency and/or urinary frequency.
 
What Will Happen During the Study: As a study participant, you will have regular contact with our study team who will monitor your health closely. There will be 8-9 or 11-12 visits during the study, which will last 9 or 16 months.  There will be a 12-week treatment period and a 14- or 40-week extension. During the treatment period there will be a 1 in 3 chance you will receive placebo. After completing the treatment period, you will be randomized into an extension period where all patients receive active study drug.
 

For Additional Study Information: 

 

Chronic Pain Studies

 

Understanding Relationships Between Chronic Non-Cancer Pain, Pain-Related Psychosocial Factors, and Exercise Participation  

Researchers at the University of Saskatchewan, College of Kinesiology are studying what people with chronic pain experience in their lives, including what beliefs might relate to their exercise levels.

Participants in this study must be at least 18 years of age, had pain for at least six months, and tried to exercise at least once since the pain started.

Volunteers will be asked to complete three online surveys. Click here to view the informed consent form as well as additional information on how to particpate in this study.

 

Temporomandibular Disorders Studies

Patients Needed in Baltimore MD Area: Biobehavioral Pain Management in TMD Research Study

Researchers at Johns Hopkins School of Medicine and the University of Maryland Dental School are looking for volunteers with widespread pain that includes jaw pain (TMD) to participate in a research study to investigate the effect of three different non-drug treatments on pain and sleep symptoms. If you have fibromyalgia and jaw pain you may be eligible. For additional information, please read through the study information brochure and patient consent form.  

 

Patients Needed in Baltimore MD Area: Study on Genetics and Facial, Jaw and Headache Pain

Researchers at the University of Maryland School of Nursing asked us to post the following announcement on a research opportunity for patients.

Chronic orofacial pain represents an economic burden both in the United States and worldwide affecting 5-10% of the population. Researchers at the University of Maryland, Baltimore have developed a novel and comprehensive genetic, behavioral and imaging approach to study the role of genetic variations on pain mechanisms in healthy participants as well as participants with facial, jaw and headache pain.

Who is eligible to participate?

You may qualify if you:

  • Are 18-65 years of age.
  • Speak and understand English.
  • Are either in good health, or you have had recent headaches, facial pain, and/or jaw pain.

This research study requires:

  •  One screening visit for ensuring eligibility.
  •  One experimental study session lasting no more than four hours.

Compensation for all sessions and parking vouchers are provided. If you are interested, please email CollocaLab@son.umaryland.edu or call 410-706-5975

For more information, please read the informational flyer.

 

Comparative Study of Women Considering or Currently Receiving Botox© Injections for TMJ Pain

Are you a woman within the Los Angeles or New York City areas with TMJ pain in facial muscles, who has either:

a. recently had Botox© injections for your pain or

b. not had Botox© for your pain but has thought about such treatment?

If either is true for you, you may qualify for an observational research study centrally administered by the New York University College of Dentistry. It is funded by the National Institutes of Health (NIH). The purpose of this study is to understand potential health risks that may be caused by treating "TMJ pain" with Botox© injections. Potentially eligible women must first complete a brief interview via telephone to confirm eligibility. Click here for further study information and details.   

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